The role of ovarian hormones in initiating the induction of mammary cancer in rats by polynuclear hydrocarbons.
نویسنده
چکیده
The current studies demonstrate the critical importance of ovarian hormones in the initiation and promotion of carcinogenesis of mammary glands in rats by polynuclear hydrocarbons. Removal of ovarian hormones from the rats immediately after the ad ministration of the carcinogenic hydrocarbons either inhibited or profoundly reduced the incidence of mammary cancer. Excision of ovaries beyond 7 days after feeding of carcinogenic hydrocarbon, however, was unable to prevent or to reduce significantly the incidence of mammary cancer in these rats. Likewise, feeding of carcinogenic hydro carbons to already castrated rats failed to induce any mammary cancer if the time be tween castration and feeding of carcinogen was prolonged. These experiments suggest that neoplastic transformation in the cells of the mammary glands in rats cannot take place in the absence of the participation of ovarian hormones, since subsequent supply of ovarian hormones from the functioning grafts failed to produce any mammary cancers. The experiments also indicate that there may be a quantitative balance between the carcinogenic polynuclear hydrocarbon and the hormones which govern the induction of mammary cancer in rats. In a small number of rats, a potent carcinogen was capable of inducing cancer in the mammary glands in which the metabolic activity was de creasing after the removal of ovarian hormones, whereas a "less potent" carcinogen
منابع مشابه
Mammary Cancer in Rats by Polynuclear Hydrocarbons The Role of Ovarian Hormones in Initiating the Induction of Updated Version
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ورودعنوان ژورنال:
- Cancer research
دوره 22 شماره
صفحات -
تاریخ انتشار 1962